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FLASH GENE
Symbol SLX1A contributors: mct/npt - updated : 19-05-2014
HGNC name SLX1 structure-specific endonuclease subunit homolog A
HGNC id 20922
RNA
TRANSCRIPTS type
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 1170 - 275 - 2009 19596235
5 - 828 - 161 - 2009 19596235
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus    
Reproductivefemale systemuteruscervix  
Skin/Tegumentskin    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a GIY-YIG-type nuclease domain
  • HOMOLOGY
    Homologene
    FAMILY
  • SLX1 family
  • CATEGORY enzyme , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • regulator of structure-specific nucleases and with BTBD12 are important regulators of genome stability in human cells (Munoz 2009)
  • in addition to 5prime flap endonuclease activity, SLX1A-BTBD12 has a robust Holliday junction resolvase activity (Fekairi 2009)
  • with BTBD12 have important functions in the maintenance of genome integrity and in the tolerance to DNA damage inflicted by an alkylating agent (Fekairi 2009)
  • resolvase that processes Holliday junctions during homologous recombination-mediated DNA double strand break repair
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SLX1A-BTBD12 module promotes symmetrical cleavage of static and migrating Holliday junctions (HJs), identifying GIYD1-BTBD12 as a HJ resolvase (Svendsen 2009)
  • coordinated actions of SLX1A-BTBD12 and MUS81-EME1 for Holliday junction resolution
  • SLX1A, and SLX1B like MUS81-EME1, is required for repair of DNA interstrand crosslinks, but this role appears to be independent of Holliday junctions (HJs) cleavage
  • GEN1 and the BTBD12-associated nucleases MUS81 and SLX1A and SLX1B are essential for the resolution of replication-induced Holliday junctions '
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS