basic FUNCTION
| may serve as an effector for endomembrane-associated RAS |
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can promote transformation |
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is required for endothelial cell motility, angiogenesis and vessel formation |
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RASIP1 is a unique, endothelial-specific regulator of RHO GTPase signaling, which is essential for blood vessel morphogenesis |
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RASIP1 is a RAP1A-effector involved in cell spreading and endothelial barrier function |
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RAP1A and its effector RASIP1 as critical mediators of endothelial junction stabilization, and the relationship between RAP1A effectors and modulation of different subsets of endothelial junctions |
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HEG1, a transmembrane receptor, and RASIP1, an endothelial-specific RAP1A-binding protein, are both essential for cardiovascular development |
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is thus necessary in growing embryonic blood vessels, postnatal angiogenic sprouting and remodeling, but is dispensable for maintenance of established blood vessels |
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is an endothelial-specific RAP1A and Ras effector, important for vascular development and angiogenesis |
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is essential for lymphatic lumen maintenance during embryonic development by regulating junction integrity, as RASIP1 loss results in reduced levels of junction molecules and defective cytoskeleton organization |
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RASIP1 regulates likely CDC42 activity to regulate cell junctions and cytoskeleton organization, which are both activities required for lymphatic lumen maintenance |