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FLASH GENE
Symbol RASIP1 contributors: mct - updated : 17-09-2018
HGNC name Ras-interacting protein 1
HGNC id 24716
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 3311 - 963 - 2004 15031288
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Endocrinepancreas   lowly
Reproductivefemale systemuteruscervix  
 female systemovary   
 female systemplacenta  lowly
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES basic
STRUCTURE
motifs/domains
  • one dilute domain
  • one Ras-associating domain
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Rasip1 (95.1pc)
    homolog to rattus Rasip1 (95.4pc)
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,nuclear envelope
    text localized to perinuclear, juxta-Golgi vesicles and is recruited to the Golgi by activated Ras
    basic FUNCTION
  • may serve as an effector for endomembrane-associated RAS
  • can promote transformation
  • is required for endothelial cell motility, angiogenesis and vessel formation
  • RASIP1 is a unique, endothelial-specific regulator of RHO GTPase signaling, which is essential for blood vessel morphogenesis
  • RASIP1 is a RAP1A-effector involved in cell spreading and endothelial barrier function
  • RAP1A and its effector RASIP1 as critical mediators of endothelial junction stabilization, and the relationship between RAP1A effectors and modulation of different subsets of endothelial junctions
  • HEG1, a transmembrane receptor, and RASIP1, an endothelial-specific RAP1A-binding protein, are both essential for cardiovascular development
  • is thus necessary in growing embryonic blood vessels, postnatal angiogenic sprouting and remodeling, but is dispensable for maintenance of established blood vessels
  • is an endothelial-specific RAP1A and Ras effector, important for vascular development and angiogenesis
  • is essential for lymphatic lumen maintenance during embryonic development by regulating junction integrity, as RASIP1 loss results in reduced levels of junction molecules and defective cytoskeleton organization
  • RASIP1 regulates likely CDC42 activity to regulate cell junctions and cytoskeleton organization, which are both activities required for lymphatic lumen maintenance
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
  • RASIP1-ARHGAP29 pathway also functions in RAP1A-mediated regulation of endothelial junctions, which controls endothelial barrier function
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with Ras in a GTP-dependent manner (requires an intact Ras core effector-binding domain for this interaction)
  • interacting with RAP1A, RAP2A, RRAS2, RRAS
  • RASIP1 mediates RAP1A1-induced cell spreading through its interaction partner Rho GTPase-activating protein 29 (ARHGAP29), a GTPase activating protein for RHO proteins
  • RASIP1 cooperates with its close relative RAS-association and dilute domain-containing protein (RADIL) to inhibit RHO-mediated stress fiber formation and induces junctional tightening
  • RAP1A effectors RADIL and RASIP1, together with the RHO GTPase activating protein ARHGAP29, mediate RAP1A-induced inhibition of RHO signaling in the processes of epithelial cell spreading and endothelial barrier function
  • HEG1 binds directly to RASIP1 (RASIP1 localizes to forming endothelial cell (EC) cell-cell junctions and silencing HEG1 prevents this localization)
  • binding of HEG1 to RASIP1 mediates RAP1A-dependent recruitment of RASIP1 to and stabilization of EC cell-cell junctions
  • is essential for vessel formation and maintenance in the embryo, but not in quiescent adult vessels
  • RASIP1 suppresses actomyosin contractility via inhibition of RHOA by ARHGAP29, allowing controlled expansion of vessel lumens during embryonic growth
  • RASIP1 can act as a RAP1A and RAS effector and RASIP1 defines a subgroup of dimeric RA domains that could mediate cooperative binding to membrane-associated RAS superfamily members
  • RASIP1 regulates CDC42 activity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • lymphatic endothelial cell-specific Rasip1-deficient mouse embryos exhibit enlarged and blood-filled lymphatics at embryonic day 14.5
  • mice lacking Rasip1 fail to form patent lumens in all blood vessels, including the early endocardial tube