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FLASH GENE
Symbol TRIM55 contributors: mct - updated : 27-09-2023
HGNC name tripartite motif-containing 55
HGNC id 14215
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 splicing 2679 60.3 548 - 2020 31866377
11 splicing 2767 60 540 - 2020 31866377
  • having an additional exon within the coding region compared to variant 1, which causes a frameshift
  • 9 splicing 2391 50.7 452 - 2020 31866377
  • lacking an in-frame exon within the coding region compared to variant 1
  • 5 splicing 1758 26.7 241 . detected specifically in cardiac muscle 2020 31866377
  • lacking four exons within the coding region compared to variant 1
  • remaining the same translation frame
  • may bind variants 1, 2 and 3
  • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   predominantly
    Digestiveliver   moderately
    Respiratoryrespiratory tractlarynx  moderately
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatum  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text abundant in the fetal heart
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a RING-type zinc finger
  • a B-box type-2 zinc finger
  • a coiled-coil domain
  • a COS (C-terminal subgroup one signature) domain
  • mono polymer homomer , heteromer , oligo
    HOMOLOGY
    interspecies ortholog to murine Trim55 (85.8 pc)
    ortholog to rattus Trim55 (85.3 pc)
    Homologene
    FAMILY
  • C-II TRIM family
  • MURF subfamily
  • RBCC family
  • CATEGORY adaptor , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • may regulate gene expression and protein turnover in muscle cells
  • acting as a transient adaptor
  • playing a regulatory role in the assembly of sarcomeres
  • acting as an ubiquitin-protein ligase
  • TRIM55 inhibits Colorectal tumor development via, at least in part, enhancing protein degradation of MYC
  • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS development
    text
  • muscle development
  • PATHWAY
    metabolism
    signaling signal transduction
    a component
  • homooligomer
  • heterooligomer (probable)
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interacting with titin/TTN
  • myosins
  • SQSTM1
  • NBR1
  • TRIM63
  • TRIM54
  • SUMO3 or SUMO3-modified proteins modulate likely the localization, stability, and RING ubiquitin ligase activity of TRIM55
  • cell & other
    REGULATION
    Other downregulated during cardiac development
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to heart failure
    Variant & Polymorphism other
  • TRIM55 E140K variant demonstrated a number of functional implications for cardiomyocyte functions and suggest a novel role for TRIM55 polymorphism in predisposing to heart failure
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    targeting TRIM55 could provide a new therapeutic approach for CRC patients
    ANIMAL & CELL MODELS