SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,nucleus,chromatin/chromosome
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| intracellular,nucleus,nucleolus
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text
| expression level for all five genes (ARGFX, DPRX, LEUTX, TPRX1) crashes after the morula stage, and the genes are not strongly expressed again in embryonic, foetal or adult tissues |
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clearly localised to the nucleus, apart from nucleoli |
basic FUNCTION
| playing a role in the regulation of transcription, DNA-dependent |
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LEUTX may have originated by tandem duplication from the CRX gene in the Otx gene family, or from the mammalian TPRX1 gene which itself may have originated from CRX |
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ARGFX, TPRX1 LEUTX, DPRX genes arose by asymmetric evolution from the CRX homeobox gene at the base of eutherian evolution, as part of a dynamic series of duplications |
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ARGFX, LEUTX and TPRX1 regulate a set of developmentally-important genes precisely modulated at the time when the earliest cell fate decisions are made |
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ETCHbox (Eutherian Totipotent Cell Homeobox) gene |
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partial overlap of function between LEUTX and TPRX1 |
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PRD-like homeodomain protein implicated in the regulation of human embryo genome activation and preimplantation embryo development |