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FLASH GENE
Symbol BRINP3 contributors: mct - updated : 25-09-2014
HGNC name bone morphogenetic protein/retinoic acid inducible neural-specific 3
HGNC id 22393
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 2742 - 664 - 2017 28351617
8 - 2884 - 766 - 2017 28351617
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   predominantly
Reproductivefemale systembreastmammary gland moderately
 male systemprostate  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal   Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Cardiovascularendothelial cell Homo sapiens
Skeletonosteoblast Homo sapiens
cell lineage
cell lines
fluid/secretion blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains MACPF domain
HOMOLOGY
interspecies ortholog to rattus Brinp3
Homologene
FAMILY BRINP family
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION extracellular
    plasma membrane
    intracellular
intracellular,cytoplasm,organelle,mitochondria
intracellular,cytoplasm,organelle,endoplasmic reticulum
text
  • localized to the mitochondria
  • basic FUNCTION
  • possible physiological functions of BRINP family members in the development of the nervous system
  • potential role for this molecule in smooth muscle cell proliferation and senescence
  • may be a novel tumor suppressor gene (TSG) in tongue squamous cell carcinoma
  • contributes to aggressive periodontitis
  • enhances osteoblast differentiation in differentiated osteoblasts, and the effects of the conditioned medium from BRINP3-modulated myoblastic cells were positively correlated with the effects of BRINP3 on osteoblast phenotype in osteoblasts
  • having an important role in the proliferation and senescence of cells
  • may be an important humoral bone anabolic factor produced by muscle cells
  • might be an important humoral bone anabolic factor produced from muscle cells
  • has an anabolic effect in differentiated osteoblasts, although it suppresses the differentiation of myoblasts into osteoblasts
  • in endothelial cells, when BRINP3 is upregulated in response to inflammatory stimuli, it increases the expression of leukocyte adhesion molecules by increasing ROS production and NFKB1 activity
  • contributes to the TNF-induced expression of leukocyte adhesion molecules in vascular endothelial cells (ECs)
  • is an N-glycosylated protein and N-glycosylation is necessary for the secretion of BRINP3
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction of BRINP3 with UDP-glucose:glycoprotein glucosyltransferase 1 (UGGT1), a glycoprotein folding-sensor enzyme
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    FAM5C mRNA expression was significantly higher in aggressive periodontitis
    Susceptibility
  • to myocardial infarction
  • to peri-implantitis, independently from the presence of chronic periodontitis
  • Variant & Polymorphism SNP
  • BRINP3 polymorphic variant rs1342913 and low level of BRINP3 expression are associated with peri-implantitis, independently from the presence of chronic periodontitis
  • Candidate gene
    Marker
  • hypermethylated BRINP3 and MYLK can be used as potential biomarkers for diagnosis and pre-warning of gastric cancer
  • Therapy target
    ANIMAL & CELL MODELS