basic FUNCTION
| possible physiological functions of BRINP family members in the development of the nervous system |
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potential role for this molecule in smooth muscle cell proliferation and senescence |
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may be a novel tumor suppressor gene (TSG) in tongue squamous cell carcinoma |
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contributes to aggressive periodontitis |
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enhances osteoblast differentiation in differentiated osteoblasts, and the effects of the conditioned medium from BRINP3-modulated myoblastic cells were positively correlated with the effects of BRINP3 on osteoblast phenotype in osteoblasts |
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having an important role in the proliferation and senescence of cells |
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may be an important humoral bone anabolic factor produced by muscle cells |
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might be an important humoral bone anabolic factor produced from muscle cells |
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has an anabolic effect in differentiated osteoblasts, although it suppresses the differentiation of myoblasts into osteoblasts |
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in endothelial cells, when BRINP3 is upregulated in response to inflammatory stimuli, it increases the expression of leukocyte adhesion molecules by increasing ROS production and NFKB1 activity |
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contributes to the TNF-induced expression of leukocyte adhesion molecules in vascular endothelial cells (ECs) |
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is an N-glycosylated protein and N-glycosylation is necessary for the secretion of BRINP3 |