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FLASH GENE
Symbol DNTTIP2 contributors: - updated : 03-04-2006
HGNC name deoxynucleotidyltransferase, terminal, interacting protein 2
HGNC id 24013
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
Endocrinepancreas   highly
Lymphoid/Immunethymus   highly
Respiratoryrespiratory tractlarynx  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two ESR1 binding regions
  • C-terminal ESR1 binding region is increased by estrogen while the binding of ERBP region at N-terminus is not affected by estrogen
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION enhancing the transcriptional activity of ESR1
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • bound to PPARG, RXRA, and ESR2
  • interacting with the DNA binding domain and the hinge region of ESR1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS