basic FUNCTION
| required for maintenance of lymphocyte LFA1 in a nonadhesive state |
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potentially important for pre-TCR and TCR signaling because it allows the efficient interaction of ZAP70 with the LAT signalosome, thus regulating thymocyte development |
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regulates FCER1A signaling in mast cells by facilitating SYK activation, possibly as an adaptor molecule for SYK |
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modulates IL3 signalling through regulation of STAT activity and IL3 receptor expression |
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key adapter protein that maintains LCK in the inactive state, contributing to the regulation of both pre-TCR (T cell receptor) and TCR signalling during T-cell development ( |
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plays a role in T development |
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regulates TCR signaling via recruitment of ZAP70 and LCK to CD247 in the immunological synapse |
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functioning as an adaptor molecule in TCR signaling pathway |
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lacking GTPase activity |