Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol DGCR2 contributors: npt - updated : 24-04-2003
HGNC name DiGeorge syndrome critical region gene 2
HGNC id 2845
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 4504 60 550 - -
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   predominantly
Digestiveliver   lowly
Nervousbrain   predominantly
Respiratorylung   predominantly
Urinarykidney   lowly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text kidney predominantly
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a ldl-receptor class a domain
  • a c-type lectin family domain
  • a vwfc domain
  • HOMOLOGY
    interspecies ortholog to murine Dgcr2
    Homologene
    FAMILY
    CATEGORY adhesion , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I membrane protein
    basic FUNCTION
  • putative adhesion receptor protein which could play a role in neural crest cells migration (a process which has been proposed to be altered in DiGeorge syndrome)
  • involved in cell-cell or cell-matrix interactions required for normal cell differentiation and migration
  • CELLULAR PROCESS cell migration & motility
    PHYSIOLOGICAL PROCESS development
    text histogenesis and organogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    in DiGeorge syndrome
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS