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FLASH GENE
Symbol CRTAM contributors: KTN - updated : 31-07-2008
HGNC name cytotoxic and regulatory T cell molecule
HGNC id 24313
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 2422 44.5 393 - -
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen   highly
 thymus   moderately
Nervousbrain   highly
Respiratorylung   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal moderately
cell lineage
cell lines
fluid/secretion predominantly in blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 17 aa signal peptide
  • an Ig-like (immunoglobulin-like) V-type domaine
  • an Ig-like (immunoglobulin-like)C2-type domains
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rattus Crtam (71.7 pc)
    homolog to murine Crtam (72.5 pc)
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • iglon family
  • nectin family
  • CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • attached to the membrane by a GPI-anchor
  • single-pass type I membrane protein
  • basic FUNCTION
  • mediating selective neuronal growth and axon targeting
  • contributing to the guidance of developing axons and remodeling of mature circuits in the limbic system
  • involved in positive regulation of cytokine secretion
  • involved in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CADM1 (could regulate a large panel of cell/cell interactions both within and outside of the immune system)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS