basic FUNCTION
| may be involved in sphingolipid synthesis or its regulation |
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key enzymes generating ceramide |
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playing a role in cancer differentiation and early embryonic development |
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regulates synthesis of a specific subset of ceramides and displays a unique substrate specificity profile for chain length and/or saturation in fatty acid acyl-CoA |
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prosurvival role of CERS6/C(16)-ceramide involved in the protection against ER-stress-induced apoptosis and induction of HNSCC tumor growth |
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important role for the CERS genes CERS2, CERS6) in breast cancer etiology or diagnosis |
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interplay among the CERS proteins (CERS2, CERS5, CERS6) in a stress stimulus-, cell type- and subcellular compartment-specific manner |
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co-expression of CERS2 with CERS4/CERS6 reversed the inhibitory effect of long chain ceramides on cell proliferation and the induction of apoptosis |
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ceramide synthesis by CERS6 has important roles in lung cancer migration and metastasis |