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FLASH GENE
Symbol CERS6 contributors: mct - updated : 03-01-2008
HGNC name LAG1 homolog, ceramide synthase 6
HGNC id 23826
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 6259 44.9 384 - Harrington (2001)
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
 vessel   moderately
Digestiveintestinelarge intestinecolon highly
 mouthtongue  moderately
Lymphoid/Immunethymus   highly
Nervousbrain   moderately
Reproductivefemale systemovary  highly
 male systemtestis  moderately
Respiratorylung   moderately
Urinarybladder   predominantly
Visualeye   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscular    
cell lineage
cell lines
fluid/secretion blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an homeobox DNA-binding domain
  • a TLC (TRAM/LAG1/CLN8) domain
  • HOMOLOGY
    interspecies ortholog to murine Lass6
    intraspecies homolog to LASS5
    Homologene
    FAMILY
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    text
  • integral to membrane
  • basic FUNCTION
  • may be involved in sphingolipid synthesis or its regulation
  • key enzymes generating ceramide
  • playing a role in cancer differentiation and early embryonic development
  • regulates synthesis of a specific subset of ceramides and displays a unique substrate specificity profile for chain length and/or saturation in fatty acid acyl-CoA
  • prosurvival role of CERS6/C(16)-ceramide involved in the protection against ER-stress-induced apoptosis and induction of HNSCC tumor growth
  • important role for the CERS genes CERS2, CERS6) in breast cancer etiology or diagnosis
  • interplay among the CERS proteins (CERS2, CERS5, CERS6) in a stress stimulus-, cell type- and subcellular compartment-specific manner
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
  • lipid biosynthesis
  • a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by MAPK10 in cerebral ischemia/reperfusion
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS