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FLASH GENE
Symbol CERS6 contributors: mct - updated : 03- 01-202
HGNC name LAG1 homolog, ceramide synthase 6
HGNC id 23826
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 6804 44.9 384 - 2018 30297675
11 - 6828 - 392 - 2018 30297675
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
 vessel   moderately
Digestiveintestinelarge intestinecolon highly
 mouthtongue  moderately
Lymphoid/Immunethymus   highly
Nervousbrain   moderately
Reproductivefemale systemovary  highly
 male systemtestis  moderately
Respiratorylung   moderately
Urinarybladder   predominantly
Visualeye   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscular    
cell lineage
cell lines
fluid/secretion blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an homeobox DNA-binding domain
  • a TLC (TRAM/LAG1/CLN8) domain
  • HOMOLOGY
    interspecies ortholog to murine Lass6
    intraspecies homolog to LASS5
    Homologene
    FAMILY
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • integral to membrane
  • basic FUNCTION
  • may be involved in sphingolipid synthesis or its regulation
  • key enzymes generating ceramide
  • playing a role in cancer differentiation and early embryonic development
  • regulates synthesis of a specific subset of ceramides and displays a unique substrate specificity profile for chain length and/or saturation in fatty acid acyl-CoA
  • prosurvival role of CERS6/C(16)-ceramide involved in the protection against ER-stress-induced apoptosis and induction of HNSCC tumor growth
  • important role for the CERS genes CERS2, CERS6) in breast cancer etiology or diagnosis
  • interplay among the CERS proteins (CERS2, CERS5, CERS6) in a stress stimulus-, cell type- and subcellular compartment-specific manner
  • co-expression of CERS2 with CERS4/CERS6 reversed the inhibitory effect of long chain ceramides on cell proliferation and the induction of apoptosis
  • ceramide synthesis by CERS6 has important roles in lung cancer migration and metastasis
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
  • lipid biosynthesis
  • a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • phosphorylation of ceramide synthases(CERS2, CERS3, CERS4, CERS5, CERS6) may be a key regulatory point in the control of the distribution and levels of sphingolipids of various acyl-chain lengths
  • FAS, a mediator of extrinsic apoptotic pathway, is a novel CERS6 binding partner
  • CEBPG facilitates lamellipodia formation and cancer cell migration through CERS6 upregulation
  • cell & other
    REGULATION
    activated by MAPK10 in cerebral ischemia/reperfusion
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in non-small-cell lung cancer (NSCLC) tissues,and is associated with poor prognosis and lymph node metastasis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • CERS6 overexpression could be a useful biomarker for predicting the outcomes of GC patients
  • CERS6 may serve as a biomarker in determining the effectiveness of anticancer agents acting via the extrinsic pathway in T-ALL
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivestomach
    CERS6 targeting represents a potential modality for treating gastric cancer (GC)
    ANIMAL & CELL MODELS