basic FUNCTION
| being essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 and which can be ADP-ribosylated by diphteria toxin and by pseudomonas exotoxin A |
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playing a possible role in the secretion process indicated by the increase of extracellular release of proteoglycans produced by the DPH3 down-regulation |
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stimulating binding of SERGEF to SEC5 |
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acting in diphthamide biosynthesis (Webb 2008) |
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in addition to having a role in diphthamide biosynthesis, is also involved in modulating the functions of the Elongator complex in yeast (Liu 2006) |
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having a physiological importance in development (Liu 2006) |