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FLASH GENE
Symbol NOXA1 contributors: mct - updated : 25-01-2011
HGNC name NADPH oxidase activator 1
HGNC id 10668
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 1650 - 483 - 2003 12716910
- - 1481 29 273 - 2007 17602954
  • truncated NOXA1 protein lacking both PB1 and SH3 domains
  • - - 1395 - 427 - 2007 17602954
  • protein lacking the activation domain due to absence of exons 5 and 6 but including a heptapeptide (EPDVPLA) SH3 domain insertion resulting from alternative splicing in exon 14
  • failed to support superoxide-generating activity and exhibited transdominant inhibition of NOXA1
  • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
    Reproductivefemale systembreastmammary gland  
     female systemovary   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four N-terminal tetratrico-peptide repeats, and PRR domain
  • a conserved "activation domain" motif
  • a PB1 domain
  • a C-terminal SH3 domain
  • HOMOLOGY
    intraspecies homolog to p67-phox
    Homologene
    FAMILY
  • NCF2/NOXA1 family
  • NOX family of NADPH oxidases
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • participating in activation of superoxide-producing NADPH oxidases
  • mediating the binding of other regulatory proteins during activation of the phagocyte oxidase, and its translocation to the membrane is triggered upon cell activation by hyperphosphorylation
  • acts in conjunction with Nox organizer 1 (NOXO1) to regulate reactive oxygen species (ROS) production by the NADPH oxidase NOX1
  • likely a key player that links oxidized low-density lipoprotein with the activation of endothelial NAD(P)H oxidase
  • with NOXO1, having a role, as well as the binding of Rac1 GTPase, for NOX1 activity
  • functional homolog of NCF2 in VSMCs (vascular smooth muscle cell) that regulates redox signaling and VSMC phenotype
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • assembly of the NOX1 oxidase complex can be regulated through reversible protein-protein interactions
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PKA-phosphorylated NOXA1 is a new binding partner of 14-3-3 protein(s)
  • interaction between NOXO1 and NOXA1 is significantly different from that between the homologous proteins of the phagocytic oxidase, suggesting that there are important functional differences between the two systems
  • SH3PXD2B, SH3PXD2A directly bind to NOXA1, and the integrity of the N-terminal PRR of NOXA1 is essential for this direct interaction with the Tks proteins
  • cell & other
    REGULATION
    Other phosphorylation of NOXA1 is a part of the feedback mechanism that functions through activation of Rac with a net outcome of negative modulation of NOX1 activity
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    bloodcoagulation 
    potential for modulation of NOXA1 expression as a viable approach for the treatment of vascular diseases
    ANIMAL & CELL MODELS
    NoxA1 expression was significantly increased in aortas and atherosclerotic lesions of ApoE(-/-) mice compared with age-matched wild-type mice