basic FUNCTION
| playing an essential role for monoubiquitination of FANCD2 |
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required to prevent accumulation of replication-associated DNA double-strand breaks |
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having an ATP-independent binding activity and an |
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ATP-dependent DNA translocase property |
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having additional activities that suggest its direct participation in DNA repair |
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may could utilize its ATP-dependent DNA-processing activity to work coordinately with BRCA2 and FANCJ in DNA repair, ultimately leading to the removal of the damaged DNA |
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could promote DNA damage tolerance in S phase |
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can specifically bind to model replication forks and Holliday junctions and move their junction points in an ATPase-dependent manner |
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could counteract the advancement of replication forks and prevent them from running into lesions and collapsing |
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playing a vital role during replication |
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might be involved in DNA processing at stalled replication forks |
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functions both inside and outside the FA core complex to maintain genome stability and to prevent tumorigenesis |
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can promote branch migration of Holliday junctions and DNA replication structure), suggesting that FANCM may provide a link between the FA pathway and DNA repair |
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can catalyze the regression or unwinding of replication forks, which can potentially lead to recombination |
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displaying DNA-dependent ATPase activity and promoting the dissociation of DNA triplexes |
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potent DNA translocase that can remodel replication fork structures to promote fork regression |
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role in DNA processing, consistent with the current view that FA proteins coordinate DNA repair at stalled replication forks |
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role of FANCM in controlling replisome progression and fork dynamics in response to replication stress |
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controls DNA chain elongation in an ATPase-dependent manner, and is may be a ringmaster in the response to replication stress by physically altering replication fork structures and by providing a tight link to S-phase checkpoint signalling |
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promotes replication through damaged DNA and the integrity of its ATPase domain is necessary for the reactivation of stalled forks after DNA damage |
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early role for FANCM in ATR-mediated checkpoint signalling by promoting chromatin retention of TOPBP1 |
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required for efficient activation of ATR by promoting TOPBP1 loading on chromatin |
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FANCM/FAAP24 complex is specifically required for the recruitment of replication protein A (RPA) to interstrand crosslinking (ICL)-stalled replication forks |
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important for resistance to interstrand crosslinks but not at the step of monoubiquitylation of the ID complex |
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FANCM translocase activity is essential for promoting replication fork stability |
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plays an essential role in maintaining chromosomal integrity by promoting the recovery of stalled replication forks and hence preventing tumourigenesis |
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UBE2T and FANCM are functionally linked to nucleotide excision repair |
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key factor imposing an upper limit on the number of meiotic crossovers |
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FANCM and FAAP24 play multiple, while not fully epistatic, roles in maintaining genomic integrity |
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histone-fold complex MHF is remodeled by FANCM to recognize branched DNA and protect genome stability |
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FANCM and BLM complex work together at stalled forks to promote both Fanconi anemia repair and replication traverse pathways of interstrand crosslinks (ICLs) |
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is a breast cancer-predisposing gene |
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CENPS and FANCM were found to prevent gross chromosomal rearrangements mediated by centromere repeats (PMID |
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role in maintaining genomic stability in meiosis and mitosis |
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