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FLASH GENE

Symbol

PLCL1

contributors: mct - updated : 12-01-2017

HGNC name	phospholipase C like 1 (inactive)
HGNC id	9063

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 8 splicing - - 1016 - 2006 1695242 longest transcript containing 8 exons exons 1 & 2 on 5'UTR start codon in exon 3 Variant 2 - splicing - Variant 2 - 997 - 2006 1695242 transcript containing 7 exons lacking of exon 3 start codon in exon 4 exons 1 & 2 on 5'UTR shortest product NM_006226 6 splicing 6608 NP_006217 - 1095 - 2006 1695242 shortest transcript containing 6 exons lacking of exons 2 & 3 start codon in exon 1 longest product

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       predominantly Urinary kidney       moderately

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	Ca2+ binding motif
	Phospholipase C catalytic domain (PLCc)

HOMOLOGY

interspecies

homolog to rattus Plcl1 (94,78 pc)

Homologene

FAMILY

CATEGORY

protooncogene , signaling

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm

basic FUNCTION	phospholipase C,epsilon,phosphatidylinositol specific
	through gonadotropin secretion, PRIP plays an important role in female reproduction
	catalyzing the hydrolysis of phosphatidylinositol 4,5 biphosphate to generate diacylglycerol and inositol 1,4,5 triphosphate mediating a wide variety of cellular stimuli
	implicated in the negative regulation of bone formation
	involved in the regulation of the phospho-states of SNAP-25 by modulating the activity of PP1, thus regulating exocytosis
	PLCL1 and GABARAP function in a complex to regulate KIF5B-mediated insulin secretion, providing new insights into insulin exocytic mechanisms
	is a multifaceted P4-inducible scaffold protein that gates the activity of major signal transduction pathways in the endometrium.
	PLCL1, PLCL2, are likely positively involved in the development of follicles via their regulation of LH-LHR signaling and estradiol secretion

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	inhibits likely regulated exocytosis through the interaction of its C2 domain with STX1A and SNAP25, potentially competing with other SNARE-binding, C2 domain-containing accessory proteins such as SYT1 and by directly inhibiting trans-SNARE complex formation
	PLCL1- deficiency impairs osteoclast differentiation, particularly at the early stages, and PLCL1 stimulates osteoclast differentiation through calcium-calcineurin-NFATC1 signaling via regulating intracellular Ca2

cell & other

REGULATION

induced by

MAZ (MAZ is involved in its expression and regulation)

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional somatic mutation deletion     deleted in small cell lung carcinoma

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS