basic FUNCTION
| inhibiting the transcriptional activity of early B-cell factor (EBF1), and regulating EBF1 activity in B-cell leukemia |
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playing a relevant role in the control of hematopoiesis and might be implicated in the development of hematopoietic malignancies |
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inhibitor of the transcription factor EBF1, implicated in the differentiation of neural progenitors and in the specification of the B-cell lineage |
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having a a possible role in development, stem cell regulation and oncogenesis |
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relevant player in the regulation of the homeostasis of the hematopoietic stem/progenitor cell compartment |
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plays an important role in the control of B-cell development by inhibiting the activity of EBF1, a master factor in B-lineage specification) |
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can antagonize B-cell development and may potentially contribute to conserve the multipotency of primitive lympho-myeloid progenitors by preventing or delaying their EBF1-driven commitment toward the B-cell lineage |
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could modulate B-cell development by suppressing |
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EBF1 activity and its molecular mechanism of action |
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appears to function as a transcriptional coactivator |
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together with EP300, adding to the functional |
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diversity of ZNF521 |
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is the intrinsic repressor of ZNF423 and hence of adipocyte commitment during BMP-induced mesenchymal precursor differentiation |