basic FUNCTION
| chloride voltage-gated channel, playing a role in the regulation of cell volume,membrane potential stabilization, signal transduction and trans-epithelial transport |
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could be implicated in epilepsy, even in the absence of mutations |
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mediates an inwardly rectified chloride conductance activated by cell swelling, low extracellular pH or membrane hyperpolarization |
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may play an important role in the regulation of cardiac pacemaker activity, which may become more prominent under stressed or pathological conditions |
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is involved in brain ion and water homoeostasis |
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is important in maintaining the volume of trabecular meshwork cells by adjusting the outflow of aqueous solutions and maintaining the fluid balance |
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functional relationship between MLC1 and CLCN2, which is probably mediated by HEPACAM, suggesting that CLCN2 participates in the pathogenesis of megalencephalic leukoencephalopathy with subcortical cysts |