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FLASH GENE
Symbol DCLK3 contributors: mct/npt - updated : 04-05-2010
HGNC name doublecortin-like kinase 3
HGNC id 19005
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 5344 73 648 - Reiner (2006)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel    
Nervousbrain   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • serine/threonine protein kinases
  • catalytic domain
  • only possessed a partial and dysfunctional Dx domain (doublecortin-like domain)(Ohmae 2006)
  • HOMOLOGY
    interspecies ortholog to murine Dcamkl3
    Homologene
    FAMILY
  • protein kinase superfamily
  • CAMK Ser/Thr protein kinase family
  • CaMK subfamily
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • involved in a calcium-signaling pathway controlling neuronal migration in the developing brain
  • may also participate in functions of the mature nervous system
  • involved in invasion, and aggressiveness of prolactin pituitary tumors (Wierinckx 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP binding
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS