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FLASH GENE
Symbol ACTR5 contributors: npt/mct/pgu - updated : 14-02-2009
HGNC name ARP5 actin-related protein 5 homolog (yeast)
HGNC id 14671
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 2479 68.2 607 - 2005 16230350
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemuterus   
 female systemovary   
 male systemtestis   
cell lineage
cell lines
fluid/secretion
at STAGE
cell cycle     cell cycle, interphase
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Actr5
Homologene
FAMILY
  • actin family
  • ARP5 subfamily
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    text
  • both ACTR5 and ACTR8 localize to the nuclei of interphase cells
  • during mitosis, ACTR5 is excluded from chromatin
  • basic FUNCTION
  • functioning as an integral component of a multisubunit ATP-dependent chromatin remodeling complex
  • functioning as an integral component of a multisubunit ATP-dependent chromatin remodeling complex
  • contributes to a wide variety of chromatin-dependent nuclear transactions, including transcription, DNA repair and DNA replication
  • ACTR8 is required for the recruitment, and ACTR5 is required for the DNA repair functions of the INO80 complex
  • is a key regulator of MYOCD activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • ATP-dependent chromatin remodeling complex
  • part of INO80 complex containing three actin-related proteins (ARPs), of which ACTR5 and ACTR8 are specific to the INO80 complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ACTR5 bound to a DNA binding domain of SRF via its C-terminal sequence and prevented the association of the MYOCD-SRF complex with the promoter regions of smooth muscle genes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS