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FLASH GENE
Symbol DNER contributors: mct/pgu - updated : 16-10-2020
HGNC name delta/notch-like EGF repeat containing
HGNC id 24456
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 3272 - 737 - 2005 15965470
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary   
Hearing/Equilibriumearinnercochlea  Homo sapiens
Nervousbrainhindbraincerebellum predominantly Homo sapiens
 brainmidbrainsubstantia nigra   Homo sapiens
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsensorystato-auditory  
cells
SystemCellPubmedSpeciesStageRna symbol
Hearing / Equilibriumepithelial cell
Nervousneuron Homo sapiens
NervousPurkinje cell Homo sapiens
Nervouspyramidal cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, fetal
Text expressed in hair cells and vestibular ganglion neurons during development and in adults
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a single transmembrane region
  • ten distincts EGF-like motifs, extracellular EGF-like repeats
  • potential tyrosine-based sorting signal
  • a typical tyrosine-type sorting signal
  • a dileucine-type sorting signal
  • HOMOLOGY
    interspecies homolog to murine Dner
    Homologene
    FAMILY
    CATEGORY signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endosome
    text PTPRZ1 and DNER displayed patchy colocalization in the dendrites of Purkinje cells
    basic FUNCTION
  • playing crucial roles in establishing the neuronal networks in the olfactory system, cerebellum, and hippocampus
  • mediates neuron-glia interaction and promotes morphological differentiation of Bergmann glia through Deltex-dependent Notch signaling
  • mediates Notch signaling by cell-cell interaction
  • contributes to the morphological and functional maturation of Bergmann glia via the Notch signaling pathway, and is essential for precise cerebellar development
  • potential role for DNER and PTPRZ1 in hair-cell development and possibly in the specification of tonotopy
  • DNER was expressed in spiral ganglion neurons (SGNs) and appeared to be involved in the mechanisms underlying neuronal polarity and neuritogenesis, via a Notch&
  • 8209;dependent signaling pathway
  • DNER promotes prostate cancer progression and the growth of PC-3 cells by modulating the primary genes of cancer stem cells
  • is an activator of the NOTCH1 pathway which has been implicated in the aetiology of neurodegenerative disorders including Alzheimer's disease
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , nervous system
    PATHWAY
    metabolism
    signaling neurotransmission
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    protein
  • may be binding to clathrin coat-associated protein complex AP1
  • neuron-specific transmembrane protein, ligand of NOTCH during cellular morphogenesis of Bergmann glia
  • transmembrane Notch ligand
  • cell & other
    REGULATION
    Other surface expression of DNER is regulated by clathrin-dependent and -independent endocytosis
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS