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FLASH GENE
Symbol TMEM165 contributors: mct - updated : 20-08-2012
HGNC name transmembrane protein 165
HGNC id 30760
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 1983 35 324 - 2012 22683087
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel   moderately
Lymphoid/Immunelymph node   moderately
 thymus   highly
Reproductivefemale systembreastmammary gland highly Homo sapiens
Respiratorylung   lowly
 respiratory tractlarynx  lowly
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cell lineage
cell lines
fluid/secretion blood
at STAGE
physiological period pregnancy
Text
  • highly expressed in the lactating mammary gland
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal signal sequence
  • 6 predicted transmembrane domains
  • HOMOLOGY
    interspecies ortholog to murine Tparl
    Homologene
    FAMILY
  • UPF0016 family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    text
  • integral to membrane
  • perinuclear Golgi-like distribution, present in the late Golgi (trans) rather than in the early Golgi (cis and median)
  • basic FUNCTION
  • important role for TMEM165 in Golgi glycosylation and Golgi morphology maintenance
  • is potentially responsible for passive proton leakage within the secretory pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CDG2K
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS