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FLASH GENE
Symbol WIPF2 contributors: mlc - updated : 20-06-2005
HGNC name WAS/WASL interacting protein family, member 2
HGNC id 30923
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly
 intestinesmall intestine  moderately
 pancreas exocrine   highly
Lymphoid/Immunelymph node   highly
Nervousbrain   moderately
Reproductivefemale systemuteruscervix predominantly
 female systembreastmammary gland moderately
cell lineage
cell lines
fluid/secretion blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a WH2 domain
HOMOLOGY
interspecies ortholog to murine Wipf2 (89 pc)
Homologene
FAMILY Verprolin family
CATEGORY adaptor , regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytoskeleton
text localized to stress fibers and bundles of actin filaments
basic FUNCTION
  • playing an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors
  • playing an important role in actin-microspike formation through cooperation with WASL
  • may cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system
  • being a potential link between the activated platelet-derived growth factor receptor and the actin polymerization machinery
  • actin bundling protein
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • WASL/WIPF2 serves as an integrator that couples actin nucleation with the subsequent steps of filament stabilization and organization necessary for zonula adherens integrity
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • WASL
  • WAS
  • NCK2
  • binds to actin filaments but also cross-links them
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS