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FLASH GENE
Symbol TM4SF4 contributors: mct - updated : 09-05-2012
HGNC name transmembrane 4 L six family member 4
HGNC id 11856
RNA
TRANSCRIPTS type messenger
text using alternate polyadenylation sites
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1624 - 202 - 2001 11267677
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon moderately Homo sapiens
 intestinesmall intestinejejunum   Homo sapiens
 liver   highly Homo sapiens
 pancreas exocrine   predominantly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
PROTEIN
PHYSICAL PROPERTIES Hydrophilic Hydrophobic
STRUCTURE
motifs/domains
  • four potential hydrophobic transmembrane domains
  • a hydrophilic region between domains 3 and 4 containing 2 potential N-linked glycosylation sites
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to rattus Tm4sf4
    ortholog to murine Tm4sf4
    homolog to xenopus tm4sf4-prov1
    Homologene
    FAMILY
  • L6 domain tetraspanin family
  • tetraspanin (TM4SF) family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • playing a role in negative the regulation of cell proliferation
  • regulating the adhesive and proliferative status of intestinal epithelial cells
  • can mediate density-dependent cell proliferation
  • potential role during endocrine differentiation
  • plays a crucial role in promotion of cancer cell proliferation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component N-linked glycosylation (required for the growth inhibitory effect)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • transcriptional target of NKX2-2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hepatocellular carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker potential to be biomarker in HCC
    Therapy target
    ANIMAL & CELL MODELS