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FLASH GENE
Symbol TAOK1 contributors: mct/npt - updated : 27-08-2019
HGNC name TAO kinase 1
HGNC id 29259
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
20 - 12096 - 1001 - 2014 24898139
18 - 11652 - 853 - 2014 24898139
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Digestiveintestinesmall intestine  moderately
 mouthtongue  predominantly
Nervousbrain   highly Homo sapiens
Reproductivefemale systembreastmammary gland moderately
cell lineage
cell lines
fluid/secretion blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal header domain
  • a catalytic domain
  • a protein kinase [amino acids 28281] domain
  • a coiled-coil motifs 1 [amino acids 458651] and 2
  • a substrate-binding domain
  • a spacer region
  • a tail domain
  • HOMOLOGY
    interspecies ortholog to murine Taok1
    Homologene
    FAMILY
  • protein kinase superfamily
  • STE Ser/Thr protein kinase family
  • STE20 subfamily
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus
    text
  • TAOK1 and TAOK2 localize to the cytoplasm and centrosomes respectively during mitosis
  • basic FUNCTION
  • activated MEK3
  • involved in the regulation of the p38-containing stress-responsive MAP kinase pathway
  • induced apoptotic morphological changes that include cell contraction, membrane blebbing, and apoptotic body formation
  • activating the polarity -inducing kinase MARK1
  • microtubule affinity-regulating kinase kinase, is also an important regulator of mitotic progression, required for both chromosome congression and checkpoint-induced anaphase delay (Draviam 2007)
  • dual functions in regulating microtubule dynamics and checkpoint signalling may help to coordinate the establishment and monitoring of correct congression of chromosomes, thereby protecting genomic stability in cells (Draviam 2007)
  • the three-way interaction between SPRED1, TAOK1, and TESK1 represents a pathway that links regulation of both the microtubule- and F-actin cytoskeleton (Johne 2008)
  • TAO kinases are potential tumor suppressor genes
  • controls various biological phenomena, including microtubule dynamics, animal behavior, and brain development
  • is required for ensuring the normal congression of chromosomes
  • is involved in the development of IL17A-related autoimmune disorders
  • induce microtubule instability via activation of microtubule affinity-regulating kinase (MARK) and phosphorylation of microtubule-associated proteins, including tau
  • plays a role in the establishment of neuronal polarity, neuronal differentiation, and early brain development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • form a subgroup of sterile 20 (STE20)-like kinases that regulate different cytoskeletal processes
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • two new interaction partners, the regulatory Sprouty-related protein with EVH-1 domain1 (SPRED1) and the testis-specific protein kinase (TESK1)(Johne 2008)
  • interacts with the checkpoint kinase BUB1B and promotes enrichment of the checkpoint protein MAD2 at sites of defective attachment, providing evidence for a regulatory step that precedes the proposed MAD2-MAD1 dependent checkpoint-signal amplification step (Draviam 2007)
  • TAOK1 functions as a negative regulator of IL17A-mediated signal transduction and inflammation
  • TAOK1 interacts with IL-17 receptor A (IL17RA) independent of its kinase activity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NDDMH
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    decreased in the colons of ulcerative colitis patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    may offer novel therapeutic targets suitable for drug inhibition and the potential treatment of breast cancers, where supernumerary centrosomes occur
    ANIMAL & CELL MODELS