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FLASH GENE

Symbol

LEPROT

contributors: mct/npt - updated : 21-10-2014

HGNC name	leptin receptor overlapping transcript
HGNC id	29477

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

text	containing the first two OB-R gene 5'-untranslated exons, but then is alternatively spliced to two novel exons which were mapped to a yeast artificial chromosome containing the leptin receptor gene

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_017526 4 - 4663 NP_059996 13.12 131 - Bailleul (1997) NM_001198683 3 - 611 NP_001185612 - 37 - - NM_002303 2 - 4161 NP_002294 - 1165 - - NM_001003679 2 - 5142 NP_001003679 - 895 - - NM_001003680 2 - 3079 NP_001003680 - 958 - - NM_001198681 5 - 4625 NP_001185610 - 140 - -

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly   vessel       predominantly Digestive liver       highly Homo sapiens Reproductive female system uterus     moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow       Connective bone

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

four potential transmembrane domains

HOMOLOGY

interspecies	ortholog to rattus Obrgrp
	ortholog to murine Obrgrp

Homologene

FAMILY	OB-RGRP/VPS55 family
	tetraspanning membrane proteins family

CATEGORY

receptor

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	mediates the weight-regulatory effects of leptin (OB protein)(Bailleul 1997)
	with LEPROTL1 influence liver GH signaling and regulation of the genes encoding these proteins may constitute a molecular link between nutritional signals and GH actions on body growth and metabolism (Touvier 2009)
	LEPROT and LEPROTL1 influence liver GH signaling and regulation of the genes encoding these proteins may constitute a molecular link between nutritional signals and GH actions on body growth and metabolism

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	FGF21 prevents the GH effects on chondrocytes by activating LEPROT and LEPROTL1
	FGF21 specifically and directly modulate LEPROT/LEPROTL1 expression and function in chondrocytes

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS