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FLASH GENE
Symbol LEPROT contributors: mct/npt - updated : 21-10-2014
HGNC name leptin receptor overlapping transcript
HGNC id 29477
RNA
TRANSCRIPTS type messenger
text containing the first two OB-R gene 5'-untranslated exons, but then is alternatively spliced to two novel exons which were mapped to a yeast artificial chromosome containing the leptin receptor gene
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 4663 13.12 131 - Bailleul (1997)
3 - 611 - 37 - -
2 - 4161 - 1165 - -
2 - 5142 - 895 - -
2 - 3079 - 958 - -
5 - 4625 - 140 - -
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
 vessel   predominantly
Digestiveliver   highly Homo sapiens
Reproductivefemale systemuterus  moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four potential transmembrane domains
  • HOMOLOGY
    interspecies ortholog to rattus Obrgrp
    ortholog to murine Obrgrp
    Homologene
    FAMILY
  • OB-RGRP/VPS55 family
  • tetraspanning membrane proteins family
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • mediates the weight-regulatory effects of leptin (OB protein)(Bailleul 1997)
  • with LEPROTL1 influence liver GH signaling and regulation of the genes encoding these proteins may constitute a molecular link between nutritional signals and GH actions on body growth and metabolism (Touvier 2009)
  • LEPROT and LEPROTL1 influence liver GH signaling and regulation of the genes encoding these proteins may constitute a molecular link between nutritional signals and GH actions on body growth and metabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FGF21 prevents the GH effects on chondrocytes by activating LEPROT and LEPROTL1
  • FGF21 specifically and directly modulate LEPROT/LEPROTL1 expression and function in chondrocytes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS