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FLASH GENE
Symbol YIPF3 contributors: mct - updated : 07-07-2020
HGNC name Yip1 domain family, member 3
HGNC id 21023
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 1507 38 350 - 2017 28286305
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticerythroblast
Blood/Hematopoieticmature hematopoietic
Blood/HematopoieticNK cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text erythroblast, liver CD34+, spleen
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a yip1 domain
  • four transmembrane alpha helices
  • a long soluble N-terminal region, which is orientated towards the cytosol, followed by
  • 5 closely stacked transmembrane domains,
  • a C terminus, orientated towards the lumen of the Golgi
  • HOMOLOGY
    interspecies homolog to rattus LOC301245
    Homologene
    FAMILY
  • YIP1 family
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • membrane or cytoplasmic molecule
  • YIPF3 is synthesized in the ER as a N-glycosylated form (40 kDa), is then O-glycosylated in the Golgi apparatus to become a lower mobility form (46 kDa) and finally becomes a higher mobility form cleaved at its C-terminal luminal domain (36 kDa)
  • primarily localise to the Golgi complex, and part of cis-Golgi-localising YIPFs (YIPF3, YIPF4 and YIPF5)
  • basic FUNCTION
  • playing an important role during hematopoiesis
  • involvement of YIPF3, YIPF4 in the maintenance of the Golgi structure
  • role for this family of proteins in regulating membrane dynamics in the endomembrane system
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS