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FLASH GENE
Symbol SLC19A1 contributors: - updated : 20-06-2006
HGNC name solute carrier family 19 (folate transporter), member 1
HGNC id 10937
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 2700 - - - Prasad
- - 630 - - K562 cells Zhang
- - 990 - - K562 cells Zhang
reverse transcription
- splicing 2839 - 591 - Cao
- splicing 3263 - 473 - Cao
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticthymus   highly
Digestiveintestinesmall intestine   
 liver    
Nervousbrain    
Reproductivemale systemtestis   
 male systemprostate   
Respiratorylung   lowly
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunelymphoblast
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
twelve transmembrane spanning segments (12TM)
conjugated GlycoP
HOMOLOGY
interspecies homolog to murine Slc19a1
homolog to Drosophila CG6574
intraspecies homolog to C.elegans C50E3
Homologene
FAMILY solute carrier family 19, folate
CATEGORY transport carrier
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • playing a role in maintaining intracellular concentrations of folate
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to spina bifida and neural tube defect
    Variant & Polymorphism SNP
  • 80G>A in spina bifida
  • polymorphism 61bp in the promoter protective against neural tube defect
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS