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FLASH GENE
Symbol SLCO6A1 contributors: mct - updated : 03-10-2019
HGNC name solute carrier organic anion transporter family, member 6A1
HGNC id 23613
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 2544 - 719 - 2003 12677006
9 - 1871 - 466 - 2003 12677006
13 - 2496 - 657 - 2003 12677006
14 - 2630 - 719 - 2003 12677006
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  specific
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • twelve predicted transmembrane domains, which is a common structure of organic anion transporters
  • HOMOLOGY
    interspecies ortholog to murine Slco6b1
    ortholog to rattus Slco6b1
    Homologene
    FAMILY
  • organo anion transporter (TC 2.A.60) family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • may be involved in the regulation of sex steroid transportation and spermatogenesis in the gonad
  • organic anion transport transmembrane protein attributed as being responsible for transporting dehydroepiandrosterone sulfate and thyroid hormones involved in the regulation of spermatogenesis in the gonad
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to major depressive disorder (MDD)
  • Variant & Polymorphism other
  • rs7734060 could be a risk locus for MDD
  • Candidate gene
    Marker
  • might be novel biomarker for tumor progression and the development of metastasis in small cell lung cancer (SCLC) patients
  • Therapy target
    SystemTypeDisorderPubmed
    cancerbrain 
    could be a target for antibody-based immunotherapy for a variety of tumors, including medulloblastoma
    ANIMAL & CELL MODELS