protein
| WTAP interacts with METTL3 and METTL14, and is required for their localization into nuclear speckles enriched with pre-mRNA processing factors and for catalytic activity of the m6A methyltransferase |
|
acute METTL14 deficiency in beta-cells induces glucose intolerance by increasing the ERN1/XBP1 pathway |
|
mechanistically, METTL14 exerts its oncogenic role by regulating its mRNA targets (e.g., MYB and MYC) through N6-methyladenosine (m6A)modification, while the protein itself is negatively regulated by SPI1 |
|
YAP1 is a direct target of METTL14 in acute kidney injury (AKI) progression |