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FLASH GENE
Symbol HINFP contributors: mct/npt - updated : 08-06-2022
HGNC name histone H4 transcription factor
HGNC id 17850
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 3302 - 517 - 2009 19170105
10 - 3185 - 517 - 2009 19170105
11 - 3312 - 517 - 2009 19170105
10 - 3264 - 540 - 2009 19170105
10 - 3195 - 517 - 2009 19170105
13 - 3588 - 270 - 2009 19170105
12 - 3533 - 517 - 2009 19170105
13 - 3455 - 270 - 2009 19170105
12 - 3357 - 270 - 2009 19170105
12 - 3338 - 270 - 2009 19170105
11 - 3283 - 311 - 2009 19170105
11 - 3240 - 270 - 2009 19170105
10 - 3049 - 270 - 2009 19170105
9 - 2994 - 311 - 2009 19170105
11 - 2438 - 445 - 2009 19170105
10 - 2321 - 445 - 2009 19170105
10 - 2243 - 419 - 2009 19170105
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
 liver   highly
Lymphoid/Immunespleen   highly
Nervousbrain   highly
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven zinc finger domains similar to the C2H2 zinc finger motif
  • a stretch of negatively charged amino acids
  • specific conserved region (PSCR) located within the C-terminus that is present in HINFP homologues of all metazoan species, required for activation of histone H4 gene transcription and contributing to DNA binding of HINFP (Medina 2008)
  • HOMOLOGY
    Homologene
    FAMILY
  • zinc finger transcription factor family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • playing a role in DNA methylation and transcription repression
  • HiNFP-dependent stabilization of NPAT may reinforce signaling through the cyclin E/CDK2/NPAT pathway and contribute to coordinate control of histone gene expression (Medina 2006)
  • unique cell cycle regulatory member of the zinc finger transcription factor family (Medina 2008)
  • in addition to histone genes, also regulates expression of nonhistone targets that influence competency for cell cycle progression (Medina 2007)
  • bifunctional transcriptional regulator that can activate or repress cell cycle controlled genes depending on the cellular context (Mitra 2007)
  • final and essential link in the CCNE1/CDK2/NPAT/HINFP pathway that is required for cell cycle-dependent activation of histone H4 genes at the G1/S phase transition (Xie 2009)
  • regulator of histone H4 gene expression in all proliferating cell types and is essential for embryonic survival beyond the blastocyst stage (Xie 2009)
  • acting as a unique and irreplaceable transcription factor that functions as part of a CDK2 responsive gene regulatory mechanism that controls progression beyond the G1/S phase transition (Xie 2009)
  • mediates cell cycle control of histone H4 gene expression to support the packaging of newly replicated DNA as chromatin
  • simultaneous loss of both HINFP and the TP53 checkpoint is detrimental to normal cell growth and may predispose to cellular transformation
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with methyl-CpG-binding protein-2 (MBD2)
  • with its cofactor p220(NPAT) are principal factors regulating histone gene expression at the G(1)-S phase cell cycle transition (Medina 2007)
  • HINFP is a co-activator in SREBF-mediated transactivation of PCSK9 gene expression
  • is essential for expression of histone H4 genes
  • transmission of maternal HINFP transcripts and zygotic activation of the HINFP gene together are necessary to control H4 gene expression in early pre-implantation embryos in order to support normal embryonic development
  • is a physiological regulator of Histone1-dependent silencing of most transposable elements, as well as many host genes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    associated with senescence in bladder cancer (BC) tissues and lower HINFP expression could predict an unfavorable outcome in BC patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS