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FLASH GENE
Symbol PPP1R13L contributors: mct/npt - updated : 21-02-2017
HGNC name protein phosphatase 1, regulatory (inhibitor) subunit 13 like
HGNC id 18838
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 3117 - 828 - Strausberg, Slee, Robinson (2008)
  • predominantly nuclear
  • binds to TP53 and inhibits apoptosis induced by TP53 overexpression
  • - - 1447 - 267 - Strausberg
  • also binds to TP53 and inhibits apoptosis induced by p53 overexpression
  • N-terminus of iASPP is entirely cytoplasmic, and the longer iASPP is located in both the cytoplasm and the nucleus
  • - - 3122 - 828 - Robinson (2008)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestivestomach   highly
    Reproductivefemale systemuterus  highly
     female systembreastmammary gland highly
    Respiratoryrespiratory tractlarynx  highly
    Skin/Tegumentskin   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • alpha helices at the N-terminus
  • coiled-coil region
  • several proline-rich regions that contain pattern 7 nuclear localization signals
  • four consecutive ankyrin repeats
  • a C-terminal SH3 domain
  • HOMOLOGY
    Homologene
    FAMILY
  • apoptosis stimulating proteins of p53 (ASPP) family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text N-terminus of PPP1R13L is entirely cytoplasmic, and the longer PPP1R13L is located in both the cytoplasm and the nucleus
    basic FUNCTION
  • evolutionarily conserved inhibitor of TP53, involved in regulation of transcription, DNA-dependent
  • having ability to regulate the apoptotic function of TP53 and its family members, TP63 and TP73
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • destabilization of CREBBP by downregulation of PPP1R13L
  • expression levels appears to represent a molecular mechanism that contributes to chemoresistance in melanoma cells
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to breast cancer, postmenopausal, before 55 years
    Variant & Polymorphism SNP SNP increasing the risk of basal cell carcinoma before age 50
    Candidate gene
    Marker
    Therapy target target for cancer therapy
    ANIMAL & CELL MODELS