basic FUNCTION
| involved in membrane fusion between sperm and egg (essentiel for fusion) |
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involved in the fertilization process in sperm |
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membrane protein that is not exposed to the outside of sperm, but is hidden under the plasma membrane before acrosome reaction |
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membrane protein that is not exposed to the outside of sperm, but is hidden under the plasma membrane before acrosome reaction |
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playing a role in oocyte-spermatozoa fusion failure |
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sperm protein that is essential for gamete fusion |
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IZUMO1 alone cannot promote sperm-egg membrane fusion, but it works as a factor that is related to the cellular surface interaction, such as the tethering of the membranes by a helical region corresponding to IZUMO1PFF-core |
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requirement of two spermatozoon factors, IZUMO1 and SPACA6, and two oocyte factors, CD9 and the IZUMO1R, has been proven in Sperm-egg fusion |
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sperm-egg fusion is the critical step in mammalian fertilization, and requires the interaction between IZUMO1 on the sperm surface and IZUMO1R on the egg surface |
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sperm protein IZUMO1 and its recently identified binding partner on the oolemma, IZUMO1R, are among the first ligand-receptor pairs shown to be essential for gamete recognition and adhesion |
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IZUMO1 and SPACA6 are likely necessary for gamete fusion and their concomitant presence would be required for the recruitment of another essential molecular actor, such as a fusogen, for the fusion to take place |
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LLCFC1, TMEM95, and SPACA6 may function cooperatively with IZUMO1 and/or unknown fusogens in sperm-oocyte fusion ( |
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IZUMO1 and C16orf92 on the sperm membrane and CD9 and IZUMO1R/FOLR4 on the oocyte membrane have been identified as fusion-required proteins |
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IZUMO1 and IZUMO1R genes form a ligand-receptor protein pair involved in the recognition of sperm and egg |
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IZUMO1 may be involved in organizing or stabilizing a multiprotein complex essential for the membrane fusion in which TMEM95 could act as a fusogen due to its possible interaction with IZUMO1 |