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FLASH GENE
Symbol RHOXF2 contributors: mct - updated : 19-06-2020
HGNC name Rhox homeobox family, member 2
HGNC id 30011
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1297 - 288 - Lehner (2004)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   lowly
Reproductivefemale systemuterus  lowly
 male systemtestis    Homo sapiensFetal
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductiveoocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a homeobox domain
HOMOLOGY
interspecies ortholog to murine Rhox gene cluster (one or more members)
Homologene
FAMILY
  • paired-like homeobox family
  • PEPP subfamily
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • regulating downstream genes and biological events in the testis
  • having conserved roles in the reproductive tract
  • testis-restricted or testis-selective protein (Hofmann 2008)
  • is involved in carcinogenesis
  • is a fast-evolving homeobox gene in primates
  • its expression increases in the second trimester during fetal testes development when gonocytes differentiate into prespermatogonia
  • potential role of RHOXF2 in regulating function of membrane and microtubules
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development , reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer , and was correlated with higher stages of tumors
    tumoral     --over  
    in some leukemia cell lines and a variety of human cancer samples including colon and lung cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • ODF4 and RHOXF2 are proposed as putative breast cancer biomarkers at the transcript level
  • Therapy target
    ANIMAL & CELL MODELS