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FLASH GENE
Symbol ISLR2 contributors: mct - updated : 15-06-2021
HGNC name immunoglobulin superfamily containing leucine-rich repeat 2
HGNC id 29286
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 4202 - 745 - 2019 30483960
4 - 4569 - 745 - 2019 30483960
4 - 4833 - 745 - 2019 30483960
4 - 4261 - 745 - 2019 30483960
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   lowly
Nervousbrainbasal nucleicaudate nucleus lowly
 braindiencephalonamygdala lowly
 brainlimbic systemhippocampus lowly
 brainhindbraincerebellum lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • immunoglobulin domain
  • leucine-rich repeat
  • HOMOLOGY
    Homologene
    FAMILY
  • leucine-rich repeat and immunoglobulin family of membrane proteins
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involvement of ISLR2 in axon guidance and cell-cell communication
  • potential role role for iSLR2 in the regulation of complex forebrain connectivity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HAAD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Linx-deficient mice develop severe hydrocephalus and die perinatally