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FLASH GENE
Symbol ZNF687 contributors: mct - updated : 24-02-2016
HGNC name zinc finger protein 687
HGNC id 29277
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 4601 - 1237 - -
10 - 5400 - 1237 - -
9 - 4531 - 1237 - -
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node   lowly
Reproductivefemale systemuteruscervix lowly
 male systemtestis  lowly
Visualeye   lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone    Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 13 C2H2-type zinc-finger
  • a strong nuclear localization signal (NLS) sequence between amino acids 938 and 954
  • HOMOLOGY
    Homologene
    FAMILY krueppel C2H2-type zinc-finger protein family
    CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may be involved in transcriptional regulation
  • plays a role in bone metabolism and it is highly expressed during osteoclast and osteoblast differentiation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • with ZMYND8 and ZNF592, is part of the transcriptional regulator complex Z3
  • INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PDB8
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    with RUNX1 in acute myeloid leukemia
    constitutional       gain of function
    during osteoclastogenesis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS