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FLASH GENE

Symbol

ISY1

contributors: mct - updated : 20-02-2013

HGNC name	ISY1 splicing factor homolog (S. cerevisiae)
HGNC id	29201

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed INM_001204890 11 - 5068 NP_001191819 - 331 - 2009 19789211 NM_020701 11 - 3778 NP_065752 - 285 - 2009 19789211

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       highly Lymphoid/Immune spleen       moderately Nervous brain diencephalon amygdala   moderately   brain hindbrain cerebellum   moderately Reproductive female system ovary     highly Respiratory lung       highly Skin/Tegument skin       highly Urinary kidney       moderately

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

ISY1 family

CATEGORY

DNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION

implicated in the first catalytic step of splicing and splicing fidelity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacts with the ATPase DHX38 to regulate the fidelity of pre-mRNA splicing
	multiple functions for SRRM2 in the splicing process, including an important role in the activation of splicing in association with ISY1

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS