basic FUNCTION
| acting as a high affinity receptor for nicotinic acid and other compounds with related pharmacology |
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being sufficient to mediate anti-lipolytic effect of niacin in adipose tissue |
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may play a role in defense mechanisms against pathogens, at least within the innate immune system |
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might be involved in the regulation of neutrophil numbers (Kostylina 2008) |
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mediates the tumor-suppressive effects of the bacterial fermentation product butyrate in colon (Thangaraju 2009) |
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playing a role in in diabetic retinopathy (Martin 2009) |
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HCAR2, HCAR3 play an essential role in the regulation of metabolic processes and immune reactions |
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possible specific role(s) of HCAR2, HCAR3 in human skin homeostasis |
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for the AAs important for HCAR1 function, the corresponding AAs or motifs in HCAR2 are also critical for HCAR2 function |
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HCAR1, HCAR2 are G protein-coupled receptors located predominantly on adipocytes that mediate anti-lipolytic effects |
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HCAR1, HCAR2 are positively correlated with PPARG gene expression in fat |
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is a tumor suppressor in mammary gland and pharmacologic induction of this gene in tumor tissues followed by its activation with agonists could be an effective therapeutic strategy to treat breast cancer |