protein
| interacts with DLC1 (is mandatory for the recruitment and transactivation functions of ER or DLC1 to the target chromatin) |
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interacts with histone H3 via its glutamic acid-rich region and such interaction might play a mechanistic role in conferring an optimal ER transactivation function as well as the proliferation of ligand-stimulated breast cancer cells |
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protein kinase C (PRKCZ) zeta is a WWC1-interacting protein (known to play an important role in synaptic plasticity and memory formation) |
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interacts with the postsynaptic protein dendrin and synaptopodin via its WW domains and is thought to play a role in synaptic plasticity and cell migration of podocytes |
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binds to a WW domain binding motif, PPXY, in the tyrosine kinase receptor DDR1 |
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interaction partner of INADL (the last four AAs of WWC1 mediated binding to the eighth PDZ domain of INADL) |
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interacting with CLSTN2 |
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associates with and activates LATS (large tumor suppressor) LATS1 and LATS2 kinases by stimulating their phosphorylation on the hydrophobic motif |
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connection between WWC1 and mammalian Hippo signaling |
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binding between WWC1 and LATS2 requires the N-terminal 86 AAs of WWC1 and the PPPY motif and AAs 667–788 in LATS2 |
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interacting with PRKCI (WWC1 suppresses apical exocytosis through inhibition of PRKCI activity in epithelial cells) |
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associates with NF2/Merlin in a Ser539 phosphorylation-dependent manner |
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PPP1CC interacts with and dephosphorylates WWC1 |
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tissue-specific differences in the regulation of WWC1 gene expression involve transcription factor TCF7L2 and a complex alternative promoter system |
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PTPN14 and WWC1 can induce the LATS1 activation independently and cooperatively |
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is a physiologically interacting reversible substrate of ataxia telangiectasia mutated (ATM) kinase |
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memory associated WWC1 is a target of MECP2 in regulating dendritic growth |
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WWC1 is an adaptor-like protein that stabilizes RAB27A, which in turn controls exosome secretion |
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WWC1 controls exosome secretion via inhibiting the proteasomal degradation of RAB27A |
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WWC1 is a novel CCDC141-binding protein that retains GRIA1 in the cytosol after internalization |