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FLASH GENE
Symbol RABEP2 contributors: mct - updated : 26-12-2018
HGNC name rabaptin, RAB GTPase binding effector protein 2
HGNC id 24817
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 2280 - 569 - 2007 17254320
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas    
Nervousbrain    
Reproductivemale systemprostate   
Urinarykidneytubuleconvoluted tubuleproximal tubule 
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialabsorptive excretoryrenal tubular epithelium  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
two collagen IV C-terminal (col4c) domains
HOMOLOGY
Homologene
FAMILY type IV collagen family
CATEGORY signaling growth factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,endosome
intracellular,cytoplasm,cytosolic
intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
intracellular,nucleus
text
  • RABEP2 localization at the centrosome is regulated by SDCCAG8
  • basic FUNCTION
  • playing a role in membrane trafficking and in homotypic early endosome fusion
  • RABEP2 is a key modulator of KDR endosomal trafficking, demonstrating the importance of RABEP2 and RAB4 for KDR signaling in endothelial cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component heterodimer with RABGEF1
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RABEP2 is a novel primed substrate of GSK3A, and thus a potential biomarker for GSK3A activity
  • RABEP2, a RAB-effector protein implicated in arteriogenesis, modulates KDR trafficking
  • encodes an endosomal recycling protein for vascular endothelial growth factor receptor-2 (VEGFR2)
  • RABEP1 and RABEP2 share a high protein sequence identity and both interact with RAB5A
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • RABEP2 expression, including its intracellular localization, may be considered a useful marker for hyperplastic and neoplastic proliferative breast disorders
  • Therapy target
    SystemTypeDisorderPubmed
    miscelleaneousvascularshock
    is a therapeutic target candidate in human ischemic stroke
    ANIMAL & CELL MODELS