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FLASH GENE
Symbol MYLPF contributors: mct/npt - updated : 15-09-2020
HGNC name myosin light chain, phosphorylatable, fast skeletal muscle
HGNC id 29824
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 657 19 169 - 2015 26663899
9 - 843 - 169 - 2015 26663899
9 - 847 - 169 - 2015 26663899
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text pancreas
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two EF-hand calcium-binding domains
  • HOMOLOGY
    interspecies ortholog to murine Mylpf
    homolog to zebrafish mylpfa
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • involved in muscle development
  • is critically important for fast and slow skeletal muscle development
  • MYLPF function is essential for muscle integrity during early development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RHOA-mediated MYLPF regulates likely the actin organization for cytokinesis during oocyte maturation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice homozygous for a null mylpf allele lack all skeletal muscle at birth