basic FUNCTION
| having ubiquitin-protein ligase activity |
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ubiquitin-conjugating enzyme (E2) in the Fanconi anemia pathway and has a self-inactivation mechanism that could be important for negative regulation of the Fanconi anemia pathway |
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with Fanconi anemia (FA) nuclear core complex are required for the S phase and DNA damage-restricted monoubiquitination of FANCD2, but FANCD2 monoubiquitination is not regulated by multiprotein complex assembly but by the formation of an active E2/E3 holoenzyme on chromatin |
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involved in the monoubiquitination reaction of FANCD2 with the FANCL protein |
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ubiquitin ligase required in the Fanconi anemia (FA) DNA repair pathway |
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UBE2T and FANCM are functionally linked to nucleotide excision repair |
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might have a function outside the Fanconi anemia pathway |
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