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FLASH GENE

Symbol

HNRNPL

contributors: npt - updated : 20-01-2005

HGNC name	heterogeneous nuclear ribonucleoprotein L
HGNC id	5045

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed HNRPL Ib - - 1895 - 456 - Kuninger HNRPL Ia - - 2129 - 589 - Kuninger

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	glycine- and proline-rich domains
	two segments of approximately 80 amino acids each that are weakly related to each other and to the ribonucleoprotein consensus sequence-type RNA-binding domains of other hnRNP and snRNP proteins
	three RNA recognition motif (RRM) domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,nucleoplasm

basic FUNCTION	playing a major role in the formation, packaging, processing, and function of mRNA
	playing a role in in transcriptional regulation

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component of the heterogenous nuclear ribonucleoprotein (HNRNP) complexes

INTERACTION

DNA

RNA	RNA binding

small molecule

protein	with APE1
	association with VEGF mRNA under hypoxia (may play an important role in hypoxia-induced post-transcriptional
	regulation of VEGF mRNA expression)
	with PTBP1

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS