basic FUNCTION
| having histone methyltransferase activity with a specificity for histone H3 in core histones |
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playing a role in the central nervous system development and function through the epigenetic histone modification |
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functions as a negative regulator in both the NFKB1- and type I interferon-mediated gene induction pathways |
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EHMT1, EHMT2 have an essential role in normal morphogenesis of the atrioventricular septum through regulation of the size of the atrioventricular cushion |
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EHMT1 is an essential Brown adipose tissue (BAT)-enriched lysine methyltransferase in the PRDM16 transcriptional complex and controls brown adipose cell fate |
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is an essential enzymatic switch that controls brown adipose cell fate and energy homeostasis |
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EHMT1, EHMT2 are epigenetic regulators involved in gamma-globin repression |
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EHMT1 and EHMT2 are differentially expressed in cortical areas |
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plays a critical and cell-autonomous role in synaptic scaling by responding to attenuated neuronal firing or sensory drive |