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FLASH GENE
Symbol HAPLN4 contributors: - updated : 05-07-2005
HGNC name hyaluronan and proteoglycan link protein 4
HGNC id 31357
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   predominantly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text fetal eyes, lens, eye anterior segment, optic nerve, retina, retina foveal and macular, RPE and choroid
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one immunoglobulin-like V-type domain
  • two link domains
  • HOMOLOGY
    Homologene
    FAMILY HAPLN family
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • stabilizing the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix
  • involved in the formation of extracellular matrix contributing to perineuronal nets and facilitating the understanding of a functional role of these extracellular matrices
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein colocalizing with BCAN in perineuronal nets
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS