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FLASH GENE

Symbol

MOGS

contributors: mct/npt - updated : 25-02-2016

HGNC name	mannosyl-oligosaccharide glycosidase
HGNC id	24862

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006302 4 - 2910 NP_006293 91 837 - Hardt (2003) NM_001146158 5 - 2584 NP_001139630 - 731 - -

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine     highly Reproductive female system ovary     highly   female system uterus cervix   highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

(Arg)3 within the N-terminal domain contains ER targeting information but not required absolutely for ER localization

HOMOLOGY

Homologene

FAMILY

glycosyl hydrolase 63 family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,lumen
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum

basic FUNCTION	removing specifically distal alpha1-2 linked glucose from the Glc (3), Man (9), GlcNAc (2) precursor after its en bloc transfer from dolichyl diphosphate to a nascent polypeptide chain in the endoplasmic reticulum
	cleaves the distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor
	first enzyme in the processing pathway of N-linked oligosaccharide
	is involved in the trimming of N-glycans

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

carbohydrate

signaling

first step in the N-linked oligosaccharide processing pathway

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

CDG2B

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS