basic FUNCTION
| potentiates but cannot initiate FAS-induced apoptosis |
|
may playing a role in regulating the resistance to apoptosis that is observed in T cells and eosinophils of atopic dermatitis patients |
|
may play a role in the recruitment of the AAA ATPase VCP |
|
negatively regulating NF1 |
|
may play a role in regulating the resistance to apoptosis that is observed in t cells and eosinophils of atopic dermatitis patients |
|
key mediator by which unsaturated FAs inhibit their own synthesis |
|
sensor for unsaturated Fatty acids (FAs) and regulator of TG (triglycerides) synthesis |
|
inhibits TG synthesis by blocking conversion of diacylglycerols (DAGs) to TGs |
|
acting as a brake that limits TG synthesis, and this brake is released when its structure is altered by exposure to unsaturated FAs |
|
key player in the other regulatory action of unsaturated FAs, namely the stimulation of TG synthesis and lipid droplet formation |
|
DERL1 and FAF2 are engaged in dislocation and degradation of lipidated APOB at lipid droplets |
|
regulates lipid droplet homeostasis |
|
FAF2 and VCP play central integrative roles in cellular energy homeostasis |