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FLASH GENE
Symbol COMMD8 contributors: mct - updated : 14-04-2021
HGNC name COMM domain containing 8
HGNC id 26036
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1455 - 181 - 2019 31088898
5 - 1461 - 183 - 2019 31088898
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
Skin/Tegumentskin    
Urinarybladder   highly
 kidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • COMM (copper metabolism gene MURR1) domain
  • HOMOLOGY
    interspecies homolog to rattus LOC289603
    homolog to murine Commd8
    Homologene
    FAMILY MURR1/COMMD1 family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • suppressing NF-kappaB not by affecting nuclear translocation or binding of NF-kappaB to cognate motifs
  • COMMD8, whose stability depended on COMMD3, was recruited to multiple chemoattractant receptors
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • COMMD3/COMMD8 complex is a specificity determinant of GRK targeting to GPCRs and represents a point of regulation for immune responses
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • COMMD8 acted in conjunction with CCDC22 to direct the degradation of IKBKB proteins
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    deficiency of COMMD8 impaired B cell migration and humoral immune responses
    tumoral     --low  
    in several non-small cell lung cancer (NSCLC) cell lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • might be a candidate for Hymenoptera Venom immunotherapy (VIT) biomarker
  • Therapy target
    ANIMAL & CELL MODELS