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FLASH GENE
Symbol CSNK1E contributors: - updated : 22-03-2007
HGNC name casein kinase 1, epsilon
HGNC id 2453
RNA
TRANSCRIPTS type messenger
text both variants 1 and 2 encode the same protein
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 2820 47.2 416 - -
- splicing 2670 47.2 416 - -
  • differing in the 5' UTR compared to variant 1
  • EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  moderately
     mouth   highly
     pancreas exocrine   moderately
    Endocrineneuroendocrinepituitary  highly
     parathyroid   highly
    Nervousnerve   highly
    Reproductivefemale systemplacenta  moderately
     female systemuteruscervix predominantly
    Respiratorylung   moderately
    Skin/Tegumentskin   highly
    Visualeye   moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES basic
    STRUCTURE
    motifs/domains
  • a protein kinase domain
  • conjugated PhosphoP
    mono polymer monomer
    HOMOLOGY
    interspecies homolog to chimpanzee CSNK1E (96.7 pc)
    homolog to rattus Csnk1e (99.3 pc)
    homolog to murine Csnk1e (98.8 pc)
    homolog to chicken CSNK1E (95.7 pc)
    intraspecies homolog to CSNKP
    Homologene
    FAMILY
  • Ser/Thr protein kinase family
  • casein kinase I subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • can phosphorylate a large number of proteins, like DVL1
  • participating in Wnt signaling
  • may act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2
  • retaining PER1 in the cytoplasm
  • inhibiting cytokine-induced granuloytic differentiation
  • CELLULAR PROCESS nucleotide, repair, base excision repair
    nucleotide, repair, recombination
    PHYSIOLOGICAL PROCESS circadian , development
    text putatively involved in DNA repair throught excision and recombination
    PATHWAY
    metabolism
    signaling signal transduction
    putatively involved in generation of complete dorsal axis and induction of genes that are direct targets of WWT signals
    a component
  • autophosphorylated
  • component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • interacting directly with PER1 and PER2 which may lead to their degradation
  • interacting with SOCS3
  • cell & other
    REGULATION
    inhibited by autoinhibition relieved by phosphatases and limited proteolysis
    Other down-regulated during granulocytic differentiation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target for pharmaceutical compounds influencing circadian rhythms, sleep, and jet lag, as well as other physiologic and metabolic processes under circadian regulation (Lowrey, 2000)
    ANIMAL & CELL MODELS
    mammalian circadian mutation tau