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FLASH GENE
Symbol CANT1 contributors: mct/npt/pgu - updated : 22-09-2015
HGNC name calcium activated nucleotidase 1
HGNC id 19721
RNA
TRANSCRIPTS type messenger
text all transcripts encode de same protein
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 3489 - 401 - 2009 19853239
5 - 3350 - 401 - 2009 19853239
4 - 3545 - 401 - 2009 19853239
characterized by eight nucleotidase conserved regions (NRC)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
 intestinelarge intestinerectum  
Nervousbrainhindbraincerebellum  
Reproductivemale systemprostate   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivecartilage  specific Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
not specificchondrocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
secondary structure dimeric nature of the soluble nucleotidase, the dimer interface containing a central core of hydrophobic residues
mono polymer dimer
HOMOLOGY
Homologene
FAMILY
  • apyrase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text
  • exists as both a membrane-bound form in the endoplasmic reticulum and pre-Golgi intermediate membranes and as a secreted, soluble form
  • basic FUNCTION
  • homologue of the salivary anti-coagulant apyrases injected by insects into their hosts to allow blood feeding
  • specific involvement in the endochondral ossification process
  • involved in chondrocyte ER metabolism
  • endoplasmic reticulum (ER)-Golgi resident Ca(2+)-dependent nucleoside diphosphatase, suggested to have a role in glucosylation reactions related to the quality control of proteins in the ER and the Golgi apparatus
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • key role of CANT1, and of the regulation of its gene by KCNIP3, in the control of protein synthesis and degradation
  • cell & other
    REGULATION
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text
  • exists as both a membrane-bound form in the endoplasmic reticulum and pre-Golgi intermediate membranes and as a secreted, soluble form
  • basic FUNCTION unknown
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DSBQS
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    CANT1-ETV4 fusion in prostate cancer
    constitutional germinal mutation      
    mutation of glutamic acid 130 (located in the dimer interface) to tyrosine increased both the tendency to form dimers and the ADPase activity
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
  • have therapeutic potential as anti-coagulant and anti-thrombotic therapeutic agents (utility in future treatment strategies for thrombotic cardiovascular diseases, including myocardial infarctions and ischemic strokes)
  • potent inhibitor of platelet aggregation and may serve as the basis for the development of a new class of antithrombotic agents
  • ANIMAL & CELL MODELS