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FLASH GENE
Symbol WDFY1 contributors: mct - updated : 18-05-2017
HGNC name WD repeat and FYVE domain containing 1
HGNC id 20451
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 4682 - 410 - 2015 25736436
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Skin/Tegumentskin    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a single FYVE domain
  • seven WD40 repeats
  • HOMOLOGY
    interspecies homolog to murine Wdfy1
    homolog to rattus LOC301549
    Homologene
    FAMILY
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • may mediate the recruitment of protein involved in membrane trafficking and cell signaling to phoshatidylinositol-3-phosphate-containing membrane
  • WDFY1 and LAMP2 can likely influence MTORC1 activity and regulate autophagy
  • crucial role for WDFY1 in bridging the TLR-TICAM1 interaction, which is necessary for TLR signaling
  • WDFY1 functioned downstream of NRP2 to promote endosome maturation, thereby influencing the endosomal trafficking of EGFR and the formation of autolysosomes responsible for the degradation of internalized cargo
  • NRP2 maintains an optimum concentration of WDFY1 by negatively regulating its expression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • TRIF signaling is a truly homeostatic pathway to maintain intestinal epithelial barrier function revealing fundamental differences in the innate immune signaling between mucosal homeostasis and tissue repair
  • a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    ion Zn2+ binding
    protein
  • WDFY1 is a crucial adaptor protein in the TLR3/4 signaling pathway
  • WDFY1 recruits the signaling adaptor TICAM1 to TLR3 and TLR4, thereby potentiating signaling from these pattern recognition receptors (PRRs)
  • NRP2 maintains an optimum concentration of WDFY1 by negatively regulating its expression
  • NRP2 inhibits WDFY1 transcription by preventing the nuclear localization of a transcription factor, BPTF
  • cell & other
    REGULATION
    Other regulation of WDFY1 transcription by NRP2 axis is a critical event in maintaining metastatic phenotype in cancer cells
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS