basic FUNCTION
| may mediate the recruitment of protein involved in membrane trafficking and cell signaling to phoshatidylinositol-3-phosphate-containing membrane |
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WDFY1 and LAMP2 can likely influence MTORC1 activity and regulate autophagy |
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crucial role for WDFY1 in bridging the TLR-TICAM1 interaction, which is necessary for TLR signaling |
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WDFY1 functioned downstream of NRP2 to promote endosome maturation, thereby influencing the endosomal trafficking of EGFR and the formation of autolysosomes responsible for the degradation of internalized cargo |
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NRP2 maintains an optimum concentration of WDFY1 by negatively regulating its expression |