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FLASH GENE
Symbol NME8 contributors: mct - updated : 12-11-2015
HGNC name NME/NM23 family member 8
HGNC id 16473
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
18 - 2327 - 588 - 2003 12909633
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis   Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivespermatid
Reproductivespermatocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a thioredoxin domain
  • three tandemly repeated NDP-kinase domains
  • several potential phosphorylation sites
  • mono polymer monomer
    HOMOLOGY
    interspecies homolog to sea urchin IC1
    Homologene
    FAMILY group II thioredoxin family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text restricted to spermatogenesis, starting at the pachytene spermatocyte level and peaking at the round and elongating spermatid stage
    basic FUNCTION
  • may catalyze the conversion of nucleoside-diphosphate to nucleoside triphosphate (CTP, GTP and UTP)
  • may be a component of sperm axonemal organization
  • required during the final stages of sperm tail maturation in the testis and/or epididymis
  • TXNDC2 and NME8, retain association with the spermatozoa after spermiation and potentially play an important role in regulating the redox status of the mature gamete
  • sperm-specific thioredoxins, TXNDC2 and NME8, are critically important in protecting these cells against the increases in oxidative stress associated with paternal age
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP binding
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ICS6
    Susceptibility
  • to osteoarthritis
  • to neurodegeneration (Alzheimer disease)
  • Variant & Polymorphism SNP
  • significant associations between 5' SNPs and osteoarthritis that hint at regulatory functions
  • NME8 rs2718058 appears to play a role in lowering the brain neurodegeneration
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS